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  #21  
Old 22-05-2023, 02:51 PM
Aldous Aldous is offline
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Remove the s and the link works.
http://sciliterature.50webs.com/TB2.htm

Last edited by Aldous : 23-05-2023 at 02:26 PM.
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  #22  
Old 28-05-2023, 08:48 PM
Aldous Aldous is offline
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Why are there pathogenic Mycobacterium species, that cause tuberculosis, leprosy, etc.? I found some articles about experiments where they infected amoebae with various Mycobacterium species including M. tuberculosis and thought the pathogenic species must have evolved from bacteria like these. Its known that some Mycobacterium species can act as parasites and/or endosymbionts with amoebae. I found this article later. TB and leprosy involve infection of macrophages.
https://en.wikipedia.org/wiki/Macrophage

Quote:
An interesting feature of many mycobacterial species is their ability to survive inside amoebae, leading to the classification of mycobacteria as ‘amoeba-resistant micro-organisms' (Greub & Raoult, 2004). The mechanisms used by macrophages and amoebae for phagocytosis, phagolysosome formation and digestion of intracellular bacteria are very similar (Allen & Dawidowicz, 1990a, b; Brown & Barker, 1999; Greub & Raoult, 2004; Winiecka-Krusnell & Linder, 2001). Reciprocally, the strategies employed by bacteria to escape destruction by macrophages or amoebae are also similar. This supports the theory that an evolutionary selection for survival in environmental protozoa has enabled intracellular pathogenic bacteria to develop the capacities necessary for survival in macrophages (Brown & Barker, 1999; Steinert et al., 1998; Winiecka-Krusnell & Linder, 2001). In this context, it is interesting that passage through amoebae can enhance the virulence of pathogenic intracellular bacteria and that there exists a correlation between the virulence of mycobacterial species and survival in amoebae (Cirillo et al., 1997).

https://www.microbiologyresearch.org...mic1512403.pdf
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  #23  
Old 27-07-2023, 12:43 AM
Aldous Aldous is offline
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Years ago, I found an old article that discussed the possibility of measles, the flu and diptheria to cause latent TB to turn active. Later, I found some other articles that mention other diseases, too, such as pertussis. Also, being infected with both HIV and TB increases the risk that the TB will turn active and the HIV infection turns into AIDS faster. The BCG vaccine for TB is used in a lot of countries, but not in the USA. Its not 100% effective, but measles, flu, diphtheria, etc. vaccines are highly effective. Preventing active TB seems to be another good reason to make sure you're vaccinated against measles, flu and diphtheria. In the summer of 2020 when I found out that the MMR vaccine provided protection against COVID, the next day I went to the pharmacy and got the first dose of the MMR vaccine and then got the second dose a month later. MMR = measles mumps rubella


This is interesting, activation of latent TB by COVID.

Activation of tuberculosis in recovered COVID-19 patients: a case report
Quote:
In these two cases, the authors observed the development of active TB after a period of COVID recovery. Two patients who were admitted to the hospital complained mainly, among other symptoms, of fever and a continuous cough after a period of COVID-19 recovery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9949802/
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  #24  
Old 29-07-2023, 07:41 PM
Aldous Aldous is offline
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A long time ago I found an old article that said that some people don't become infected with TB even after repeated exposure to it. I tried to find it again, but couldn't find it. I found two more recent articles that seemed to say that, but they were vague on that. I found this recently which appears to say this.

Quote:
Intriguingly, complete resistance to infection is observed in some individuals (termed resisters) after intense, continuing M. tuberculosis exposure.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170664/
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Quote:
“Infection resisters” are broadly defined as individuals who despite significant exposure to Mycobacterium tuberculosis remain persistently unreactive to conventional detection assays, suggesting that they remain uninfected or rapidly clear their infection early on following exposure

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774050/
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Infection free “resisters” among household contacts of adult pulmonary tuberculosis
https://journals.plos.org/plosone/ar...l.pone.0218034
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  #25  
Old 03-08-2023, 12:00 PM
Aldous Aldous is offline
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Mycobacterium marinum

I found this recently. I read about Mycobacterium marinum before. It can infect your skin and doesn't spread to the rest of your body because it can't grow at your body temperature. It often infects cold blooded animals, ie. fish and reptiles. It can make you test positive to the TB skin test. Also, if you get the BCG vaccine you will test positive, too. The BCG vaccine isn't used in the USA. M. marinum is used in TB research.

How to identify and avoid catching fish TB, Tuberculosis Mycobacterium marinum
https://www.youtube.com/watch?v=RW_U4tvtO5k

I found this years ago:
Quote:
A reactive tuberculin skin test in Anne Arundel County is more likely to represent M. marinum infection than tuberculous infection.
https://pubmed.ncbi.nlm.nih.gov/8544670/

M. marinum is in the phylogenetic tree shown in figure 1 (middle figure) here:
https://journals.plos.org/plosntds/a...l.pntd.0002544
https://od.lk/s/OV8xOTU4ODcyMDdf/MycoTree.png
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  #26  
Old 08-11-2023, 12:27 PM
Aldous Aldous is offline
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I read in one book that TB survives outside the body for about a half a year. Another book I read says TB survives under optimum conditions for a year or more. Looks like they didn't have much success here:

Attempts to revive Mycobacterium tuberculosis from 300-year-old human mummies
https://academic.oup.com/femsle/article/283/1/54/547701

Last edited by Aldous : 08-11-2023 at 07:03 PM.
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  #27  
Old 08-11-2023, 07:03 PM
Aldous Aldous is offline
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According to this book, dead TB can cause tuberculosis. There's also a lot of information in the book about the effect of sunlight on bacteria. I read in at least one place that about a hundred years ago, you could go into major cities, collect dust in public places and find TB in the dust. TB could also be found in the dirt and dust in the streets and street sweepers had high rates of TB.

Fate of Tubercle Bacilli Outside the Animal Body
by C. R. Briscoe
https://tinyurl.com/c9bk2jhk
---------------------------------------------
Here you can see a lot of paper patents you had to search before they put everything on computer databases. There were some patents going back to the 1800's and there was a lot of dust on the patents. I had an idea that there might be TB in the hundred year old dust. It would be dead by now, but if TB was in it then it might cause tuberculosis in anyone who searched these patents regularly. Two patent searchers told me they had TB skin tests and tested negative. One of them got the skin test after he had a chest x-ray after being hit by a car and the other one got a TB skin test once a year because he did counselling in a hospital.

https://www.flickr.com/photos/62345920@N00
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  #28  
Old 31-01-2024, 11:21 PM
Aldous Aldous is offline
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I posted this link earlier in this thread.
https://web.archive.org/web/20131227...ealth-disease/

The BCG vaccine is used in a lot of countries, but not in the USA. The BCG vaccine contains a live attenuated strain of bovine TB and is mainly used as a vaccine against human TB. I found some articles about L-form (cell wall deficient, CWD) BCG that can cross the placenta.

Mother-to-newborn transmission of mycobacterial L-forms and Vδ2 T-cell response in placentobiome of BCG-vaccinated pregnant women
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727158/

Presence of mycobacterial L-forms in human blood: Challenge of BCG vaccination
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514157/

I was thinking about a conspiracy theory today that I thought of after years of trying to wrap my brain around some things about TB, such as the panic and alarmism in the news (fear sells news) about active TB cases and how people look shocked when I bring up the subject of TB. I thought that one possible reason why people try to silence me and even threaten me (shoot the messenger thinking) might be because a lot of people have TB in their brains from birth which passed through the placenta before they were born. These TB brain infected people might be controlled in some way by the bacteria to try to prevent the eradication of TB and they also might threaten someone that tries to eradicate it. Also, TB infected brains might cause certain beliefs and paranoid ideas which might result in more poverty which results in more over crowding and less medical care which would result in more TB cases.

This might sound far fetched, but if you consider some other infections, for example, toxoplasmosis. A lot of cats are infected with toxoplasmosis and humans can become infected with it, too. When rats and mice get infected with it, they lose their fear of cats which makes it easier for the cats to catch the mice and rats. From what I heard, people who had motorcycle accidents have higher rates of toxoplasmosis infection compared to the rest of the population. Also, promiscuous women have higher rates of toxoplasmosis infection compared to the rest of the population, too.

Another example:
Green-banded broodsac: The brain-hijacking parasite that creates disco zombie snails
This parasitic worm crawls into the eyestalks of snails, takes over its brain then pulsates to make the mollusk look like a dancing caterpillar.
This parasitic flatworm is best known for creating disco zombies: It takes over the bodies of amber snails (Succinea) by clambering into their eyestalks and forcing them to dance to attract birds' attention.
https://www.livescience.com/animals/...-zombie-snails
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  #29  
Old 01-02-2024, 05:39 AM
BigJohn BigJohn is offline
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Very interesting articles. A lot of information to digest.
Thank you.
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  #30  
Old 21-02-2024, 02:49 PM
Aldous Aldous is offline
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Here it says 70-90% of the population of North America and Europe were infected with TB in the 18th and 19th century.
https://youtu.be/GVl5GTGSJIU?t=208
This means most of our recent ancestors were infected with TB. One thing you can do is see if you have a family history of any active TB and if you don't you probably inherited a high resistance to TB. Its known that genetics is a big factor in your resistance to TB.

1/3 of the world's population is infected with TB right now.
https://youtu.be/GVl5GTGSJIU?t=454
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