I was watching Unexplained on the History channel today and heard something about a trial in a life extension system, but missed part of it. Paul Hynek was involved in a trial, so I did an internet search for that and found some interesting links. It has something to do with reversing thymus involution with growth hormones. There's some websites that try to sell it so I'm not posting those since they're commercial websites. I found some articles about it.
First hint that body’s ‘biological age’ can be reversed
https://www.nature.com/articles/d41586-019-02638-w
Cocktail Of Drugs Gives First Hope That ‘Biological Age’ Can Be Reversed
https://www.forbes.com/sites/robinse...h=7efcd12d6dbc
TRIIM trial to target thymus
L. Bryan Ray
Thanks to the demographic transition, aging human bodies are an increasing liability for health and social systems. The risk of many age-related diseases could be reduced by thymus regeneration to improve immunological protection. In the thymus regeneration, immunorestoration, and insulin mitigation (TRIIM) trial, Fahy et al. developed a method to promote thymus function and reverse immunosenescence aging markers in nine men aged 51 to 65 years. The men were treated with recombinant human growth hormone as well as two drugs (dehydroepiandrosterone and metformin) that are used to prevent hyperinsulinemia and the diabetogenic effects of growth hormone. Effects of treatment were measured on immune cells, cytokines, and epigenetic clocks, which monitor changes in DNA methylation and indicate biological age (as distinct from chronological age). Immunological measures improved in the treated men, and epigenetic age regressed by 1.5 years after 1 year of treatment. Larger studies are required to verify the findings.
Aging Cell 18, e13028 (2019).
https://www.science.org/doi/10.1126/....366.6468.twil
dehydroepiandrosterone = DHEA
https://www.newsweek.com/drug-trial-...-years-1458204
https://www.foxnews.com/health/groud...-be-reversible
https://www.livescience.com/reverse-...lock-drug.html
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