I have always found it interesting how certain instruments/tones/pitches in music can affect us. There are pieces of music where sometimes a single note from an instrument will seem to simply "vibrate" straight through me and make me smile...and others that will make my head hurt or almost feel like a minor skin irritation!!
The music that seems to soothe/uplift me the most is Native American flute, or Gregorian Chant. I also love the harmonica, and the saxophone...

http://www.youtube.com/watch?v=HwcG3mYo5Kk