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Almost every drug comes from a natural substance. Pharmaceuticals come from either harvesting and refining them or synthesize them if that's easier/cheaper.
They are still drugs.
Watch the movie dmt it's a documentary all the folks from the study are twitchy and show effects of longterm drug use. Not saying it isn't perhaps useful in some ways, doses and cases but it's still a drug and as such has dangers and the potential to cause harm. Heck even water can kill you if you drink enough.
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