I think it is important to say that chakras cannot be open nor closed. They are 6 wheels up along the spine, and they are a tantric concept alongside the kundalini. The point of tantra is to unravel the web of existence, thus the rise of the kundalini makes the chakras dissolve into themselves leaving you open and receptive. In this space the 7 lotuses can start to truly blossom (open).
The body in itself are full of energy lines, energy centers (some lies on top of the chakras), and pleasure zones. Mental illness is a blocage in the energy flow. Bipolar is in general a lack of balance. Mani is a lack of grounding, where depression is a lack of space for growth.
I am the flower, the tree, the vine. I am the path