How about starting out by determining what not to do and whatever is left is what to do? I'm speaking in the broadest sense of categories of what not to pursue and what to pursue: Wealth, fame, power, purpose, meaning, etc.
"Research your own experience; absorb what is useful, reject what is useless and add what is essentially your own." ~ Bruce Lee
"Of a certainty the man who can see all creatures in himself, himself in all creatures, knows no sorrow." ~ Upanishads
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